Efektivitas Cotton Ball dan Sudut 45° dalam Mengurangi Kontaminasi Microglass pada Ampul Obat
Effectiveness of Cotton Ball and 45° Angle in Reducing Microglass Contamination in Medicine Ampoules
DOI:
https://doi.org/10.52263/jfk.v15i2.309Keywords:
Cotton Ball, Drug Ampoules, Microglass Particle Contamination, 45-Degree AngleAbstract
Microglass particle contamination from ampoules poses a serious concern in pharmaceutical and medical practice due to its potential health risks. This study evaluated the effect of using a cotton ball and breaking the ampoule at a 45° angle on microglass particle contamination. A quasi-experimental design was applied to 60 glass ampoules, divided into two groups: Group A (no treatment) and Group B (cotton ball and 45° angle). Samples were taken from the surface, middle, and bottom of the ampoules and analysed using the Wilcoxon test. Microscopic examination revealed significant differences between groups: Group A showed particles of varied sizes, while Group B displayed only small, uniform particles. No significant difference was found at the surface level, but the middle and bottom sections of Group B showed a marked reduction in contamination. The study concludes that applying a cotton ball and breaking ampoules at a 45° angle effectively reduces microglass particle contamination, thereby improving drug quality and safety. Implementing this technique as a standard procedure, supported by proper training for medical and pharmaceutical staff, could reduce patient risk and enhance production efficiency. Further research is needed to optimise this method for different ampoule types and pharmaceutical preparations.
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